IMDC - Institute of Medicine Dermatological of Chicago

sexta-feira, 30 de novembro de 2012

Sun Pharma to pay $230 m for US dermatology firm DUSA

Mumbai, Nov. 8:

Sun Pharmaceutical has entered into an agreement to acquire DUSA, a US-based dermatology company, for about $230 million (over Rs 1,200 crore) in cash.

“DUSA’s business brings us an entry into dermatological treatment devices, where we see good growth opportunities,” Sun Pharma Managing Director Dilip Shanghvi said, adding that the company has proven technical capabilities in photodynamic skin treatments, with USFDA approved manufacturing. DUSA , which had revenues of some $45 million for 2011, is focused on developing and marketing its Levulan (aminolevulinic acid HCl) photodynamic therapy platform. Levulan is a combination therapy approved by the US regulator for treatment of non-hyperkeratotic actinic keratoses of the face or scalp, the company said. A pre-malignant condition, seen as crusty patches of skin, this is a frequently diagnosed skin disease in the US.

In its last acquisition of Israeli generic drugs-maker Taro, Sun had been locked in a multi-country battle over three years. Sun will fund the latest transaction from its kitty of $1 billion, a company official said.

Agreement

Under the terms of the agreement, a wholly-owned subsidiary of Sun Pharma will make a tender offer for all of the outstanding common stock of DUSA at $8 a share in cash, a 38 per cent premium to the closing price of DUSA’s common stock on November 7, Sun said.

The transaction has been unanimously approved by the boards of directors of both companies and DUSA’s board has recommended that the company’s shareholders tender their shares pursuant to the tender offer.

The closing of the tender offer will be subject to certain conditions, including the tender of a number of DUSA shares that represent at least a majority of the total number of DUSA’s outstanding shares (assuming the exercise of all options and warrants and vesting of restricted shares), the expiration of the waiting period under the Hart-Scott-Rodino Anti-trust Improvements Act and other customary conditions, Sun said. jyothi.datta@thehindu.co.in

Keywords: acquition of dermatology firm DUSA by Sun Pharmaceuticals, dermatological treatment devices,

quinta-feira, 29 de novembro de 2012

Pityriasis Lichenoides

http://www.britishskinfoundation.org.uk/SkinInformation/AtoZofSkindisease/PityriasisLichenoides.aspx

What is pityriasis lichenoides?

Pityriasis lichenoides is a rare skin disorder that will not harm your general health. The condition ‘pityriasis lichenoides’ means that the rash is scaly (pityriasis) and that it was once thought to look a bit like lichen (a type of plant that lives on rocks) because it is made up of small bumpy areas.

There are two types, i) a short-lived form usually found in children (known as pityriasis lichenoides et varioliformis acuta (PLEVA)), and ii) a more long-lasting form known as pityriasis lichenoides chronica (PLC).

What causes pityriasis lichenoides?

The cause of pityriasis lichenoides is not known, but the symptoms that occur in the childhood form suggest that it may follow a viral infection. It is more common in males than females. Neither type of pityriasis lichenoides is infectious.

Is it hereditary?

No.

What are the symptoms of pityriasis lichenoides?

The main thing you will notice is raised spots that tend to come in crops. New spots can itch or irritate as they come up.

What does pityriasis lichenoides look like?

The short-lived acute form (PLEVA): There may be a mild illness with a fever. The rash starts as separate pink spots, which form a little blister and may turn black. A crust forms on the surface and drops off to leave a small scar. The spots come up in crops, and so the rash consists of spots at various stages of development; some are small pink bumps, others have small blisters on top, and others are black in colour. The rash can look like chickenpox but takes much longer to clear. It rarely affects the face, but the spots are usually scattered on the trunk and limbs.

The chronic form (PLC): The spots look less angry and are covered with a firm shiny scale. A good diagnostic pointer is the way this scale, covering the top of a spot, can be scraped off as a single chunk, to reveal a shiny brownish surface underneath. The spots fade within 3 to 4 weeks, but new spots may then arise. The rash can clear up within a few weeks or persist for years.

How will it be diagnosed?

The look of the rash suggests the diagnosis; however, PLEVA can look like chickenpox (though it lasts much longer) and PLC can look like psoriasis, lichen planus or even insect bites. The examination of a small sample of the rash (a skin biopsy) under the microscope should confirm the diagnosis.

Can it be cured?

No treatment is certain to cure pityriasis lichenoides.

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quarta-feira, 28 de novembro de 2012

Keloids

http://www.britishskinfoundation.org.uk/SkinInformation/AtoZofSkindisease/Keloids.aspx

News

Keloids

What is a keloid?
When a wound heals, it leaves a scar. A keloid is a special type of scar: one that grows too much and can even become larger than the original wound. It is not uncommon for surgical or injury scars to become a little lumpy (hypertrophic). A keloid differs from these in several ways:
A keloid can come up after very minor skin damage, such as an acne spot, or even if there has been no obvious damage to the skin at all.
It can spread outside the original area of skin damage.
It may last for many years.

Are keloids hereditary?
They can be - a tendency to get keloids certainly runs in some families.
What are the symptoms of a keloid?
Usually there are none; but some are tender, painful, itchy, or cause a burning sensation. The main problem is that their appearance may cause embarrassment. If they are very tight, they can limit movement at nearby joints.
What does a keloid look like?
Keloids look like exaggerated scars. They are raised above the skin around them and sometimes they are domed. They can extend beyond the limits of the skin damage that caused the scar to come up in the first place. They are shiny and hairless; usually they feel hard and rubbery; and new ones are often red or purple, becoming browner and sometimes paler as they age. Most people with keloids have only one or two. However some people have many, especially if they have come up after acne or chickenpox scars.
How will it be diagnosed?
Your doctor will be able to make the diagnosis of a keloid just by looking at your skin. No investigations are usually needed.
Can a keloid be cured?
It is unusual for a keloid to be cured after treatment. The main problem is that cutting a keloid out often leads to an even bigger one forming later in the same place.
For information on available treatments please visit this page on the website of the British Association of Dermatologists

terça-feira, 27 de novembro de 2012

Dry skin facts

Dry skin is a very common condition that causes small fine flakes and dry patches.
Itching is one of the most common symptoms of dry skin.
Scratching may be hard to resist.
Dry skin is more common in colder winter months and drier climates.
The elderly are more prone to dry skin than younger people.
Dry skin is more common in individuals with a history of eczema, atopic dermatitis, allergies, or asthma.
Dry skin may rarely be a side effect of medications.
Dry skin is more common in those with hypothyroidism and hyperthyroidism.
Repeat itch-scratch cycles may lead to skin thickening and darkening.
Possible complications include rashes, eczema, and bacterial infections.
Extremely dry skin can cause cracks and breaks on the skin.
Medications including topical corticosteroids and oral antihistamines can help ease itching.
Secondary infections may result from scratches and skin breakdown.
Topical or oral antibiotics may be necessary for secondarily infected dry skin.
Several home remedies, such as decreasing bathing frequency and lubricating the skin with thick moisturizers after showers, can help control and prevent dry skin.

What is dry skin?

Dry skin is a very common skin condition characterized by a lack of the appropriate amount of water in the most superficial layer of the skin, the epidermis. While dry skin tends to affect males and females equally, older individuals are typically much more prone to dry skin. The skin in elderly individuals tends to have diminished amounts of natural skin oils and lubricants. Areas such as the arms, hands, and particularly lower legs tend to be more affected by dry skin. Dryness of the skin is affected by the amount of water vapor in the surrounding air, the humidity. Dry skin is also known as xeroderma.
Dry skin may be a mild, temporary condition lasting a few days to weeks. Dry skin may also become a more severe, long-term skin problem for some. Symptoms of dry skin include discomfort from skin tightness and itching. In addition, external factors such as weather can affect the severity of skin dryness. For example, cold or dry air and winter weather can worsen dry skin. Individuals whose occupations require more frequent hand-washing and sanitizing may experience dry skin more often. Dry skin may also be a side effect of some medications or a symptom of an underlying medical disorder.
The epidermis is normally composed of fat (lipid) and protein. The lipid portion of the epidermis helps prevent skin dehydration. When the skin's fatty oils are removed, the skin loses its protection and loses moisture more easily. As skin becomes dry, it also may become more sensitive and prone to rashes and skin breakdown. This condition is sometimes referred to as xerosis. Dry skin may be an entirely invisible skin condition, or may cause a fine dry powder-like appearance of the skin. Untreated, dry skin may become irritated and result in a red rash (xerodermatitis).
Simple prevention and treatment measures are very effective in the treatment of dry skin. Basic dry skin prevention steps include avoidance of harsh soaps and chemical cleansers. Treatment generally requires more frequent and regular applications of bland emollients and moisturizers. Untreated, dry skin may result in complications, including rashes, eczema, secondary bacterial infections, cellulitis, and skin discoloration. Fortunately, dry skin is usually mild and can be easily remedied.

segunda-feira, 26 de novembro de 2012

Eminence Organic Skin Care to Plant a Tree for Every Product Sold

http://www.marketwatch.com/story/eminence-organic-skin-care-to-plant-a-tree-for-every-product-sold-2012-11-26

The spa industry's leading organic skin care brand takes its long-standing commitment to the environment to a new whole new level to fight global climate change.

VANCOUVER, BRITISH COLUMBIA, Nov 26, 2012 (MARKETWIRE via COMTEX) -- Imagine if your daily skin care routine was an active contribution to the fight against climate change. By choosing Eminence Organic Skin Care ( www.eminenceorganics.com ), you can do just that. Taking their commitment to the environment to a whole new level, Eminence is thrilled to announce an exciting new environmental initiative: Starting November 26th, one tree will be planted for every product sold!

Every time one of their active organic or Biodynamic(R) products is purchased, a portion of the proceeds will go towards planting a tree to help clean up the air and support the world's natural resources. Every product they sell will now equal one tree planted around the world. In the first year of the program they are estimated to plant the equivalent of over 1000 football fields of trees.

"We're so excited about our Forests for the Future initiative. Planting even just one tree can make such a difference," said President and Founder of Eminence, Boldijarre Koronczay. "Deforestation is the leading cause of climate change. If we want to protect the future of our planet, and our own health, tree planting has to be a part of the plan. We're committed to rebuilding and restoring the environment one product--and now one tree--at a time."

The world loses millions of acres of trees due to deforestation every year. In just a year, one tree has the ability to produce 260 pounds of oxygen and absorb as much carbon as a car produces driving 26,000 miles. Trees also lower air temperature, stabilize soil and contribute to the fertility of land. Through partnerships with award-winning global tree planting organizations like Trees for the Future ( www.treesforthefuture.org ), Eminence Organic Skin Care is not only committed to beautiful skin with premium organic skin care, but restoring and rebuilding the environment for a healthier, and more beautiful, planet.

About Eminence

Voted "Favorite Skin Care Line" by skin care professionals 4 years in a row, Eminence Organic Skin Care is the award-winning provider of the most effective organic and Biodynamic(R) skin care products. With more than half a century of herbal craftsmanship and several centuries of unsurpassed skin rejuvenation techniques unique to Hungary, we offer the highest quality skin care to leading salons, spas and their clients in 24 countries around the world. Our superior spa treatments and products rely on a unique combination of hand-picked fresh ingredients which are hand-mixed with pure waters drawn from thermal hot springs. Vitamins are captured in their all-natural fresh base, offering dramatic results as actual seeds, pulps and peels begin the regenerative and healing powers that only nature can produce. Since our inception in 1958, Eminence has been committed to creating products that are kind to the environment by using sustainable farming and green practices.

KUALA LUMPUR: Safi Balqis Perfect 10 recently announced three of their latest products.

Wipro Unza (Malaysia) Sdn Bhd product group manager Mahsuri Sulaiman said: "The new trio define our determination in giving young females in Malaysia beauty products that meet their skin requirements."
The range consist of Safi Balqis Perfect 10 Oil Control Moisturising Lotion SPF15; Safi Balqis Perfect 10 Miracle Gel; and Safi Balqis Perfect 10 BB Cream SPF30PA++.
"The range has a unique formula which contains Nano BioWhite that works efficiently in the skin cells," she said.
She said that tests have shown that the products lighten skin within 14 days.
The SPF15 moisturising lotion is a water-based formulation which is also a brightening lotion which helps to protect and repair skin.
It comes in airless pumps and retails at RM19.90 for a 40g pack.
The gel is a gentle formulation which helps to exfoliate and remove blackheads effortlessly.
It is priced at RM16.90 (40g).
The SPF30PA++ BB cream, which is enriched with Vitamin E, is also a make-up base and is priced at RM19.90 for a 20g pack.
The brand ambassador Shila Amzah said that she was glad to share the secret of her confidence.
"I hope women out there will be more confident when they use the Safi Balqis Perfect 10 range," she said.

Read more: Products to protect, brighten skin - Central - New Straits Times http://www.nst.com.my/streets/central/products-to-protect-brighten-skin-1.170625#ixzz2DLgSUlgf

KUALA LUMPUR: Safi Balqis Perfect 10 recently announced three of their latest products.

sexta-feira, 23 de novembro de 2012

Avita Gel

http://www.medilexicon.com/drugs/avita_gel_221.php

Company: Penederm
Approval Status: Approved January 1997
Treatment for: acne
Areas: Dermatology / Plastic Surgery
Possible similar drugs: Avita Gel

| General Information | Clinical Results |

General Information

Avita cream, a topical form of retinoic acid, has been approved for the treatment of acne. The two Avita formulations approved contain .025 percent retinoic acid (tretinoin) as the active ingredient. These strengths represent the largest segment of prescriptions written for retinoic acid acne treatment.
Avita is a unique formulation of retinoic acid (tretinoin) and Penederm?s patented TopiCare Delivery Compounds. TopiCare Delivery Compounds are liquid polymers that deposit and hold drugs and other skin care agents in the upper layers of the skin. TopiCare Delivery Compounds are currently in wide use to enhance moisturizers, cosmetics and other skin care products.

Clinical Results

Avita formulations have been tested in 1,500 subjects at over 24 clinical sites in North America.

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Avita Gel Drug Information

The Avita Gel drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

quinta-feira, 22 de novembro de 2012

Lichen Sclerosus

What is lichen sclerosus?
Lichen sclerosus is a relatively uncommon condition in which thin white crinkly patches appear on the skin. It can appear anywhere, but is most troublesome in the genital areas.
What causes lichen sclerosus?
The cause of lichen sclerosus is not known. Sometimes it is associated with diseases in which the body’s immune system attacks normal tissues such as the thyroid gland (causing an over- or underactive thyroid gland) or the insulin-producing cells in the pancreas (causing diabetes).
Lichen sclerosus can occur in either sex and at any site, but is more common in women, in whom the vulva is the most common site. Lichen sclerosus can affect women of any age and may occasionally develop in girls prior to puberty. A similar process affects men and boys. Despite the tendency to affect genital skin, lichen sclerosus is not an infection - it is quite certain that the disease is not contagious, so sexual partners cannot pick it up.
Is lichen sclerosus hereditary?
No, rarely lichen sclerosus can occur in relatives.
What are the symptoms of lichen sclerosus?
Many patients have none, but the most common symptom of lichen sclerosus is itch. As a rule the spots on the general skin surface seldom itch much, but those in the genital area do, and can also be sore if the skin breaks down or cracks. In the genital area, the scar-like process can tighten the skin, and this can interfere with sexual intercourse in affected men or women. In men, lichen sclerosus can make the foreskin tight and difficult to retract, and can even partly block the flow of urine.
What does lichen sclerosus look like?
On the main areas of the skin, the spots of lichen sclerosus look like small ivory-coloured slightly raised areas, which can join up to form white patches. Some have tiny yellowish horny plugs within the pale areas. After a while the surface of the spots can look like wrinkled tissue paper. The most common sites are the bends of the wrists, the upper trunk, around the breasts, the neck and armpits.
Women with lichen sclerosus in other areas of the body often have it on the vulva as well. Sometimes this causes no symptoms and they may not even know it is there. The white thin fragile areas surrounding the vulva and the anus in a figure of eight pattern have a crinkly surface; their fragility may lead to easy bruising and erosions. Later on, the inner lips of the vulva and its opening can shrink, leading to pain on intercourse, but this is unusual in most cases. Less often lichen sclerosus can develop in young girls then get better at puberty. A similar process in men affects the penis (balanitis xerotica obliterans). It can make retraction of the foreskin difficult and interfere with passing water.
How will lichen sclerosus be diagnosed?
The diagnosis of lichen sclerosus can usually be made from the typical appearance of the condition. However, lichen sclerosus can look a bit like vitiligo (though this has a normal skin texture) and lichen planus (which is more purple). If there is any doubt, the examination of a small specimen of skin (a biopsy) under the microscope will help.
Can lichen sclerosus be cured?
No treatment is sure to reverse the changes of lichen sclerosus completely, but the symptoms and signs of the disease can usually be well controlled with a steroid application.
For information on available treatments please visit this page on the website of the British Association of Dermatologists