Cutaneous malignant melanoma is a cancer of the pigment cells of the
skin. If it is treated early, the outlook is usually good. It is not
contagious.
The word ‘melanoma’ comes from the Greek word ‘melas’, meaning
black. Melanin is the dark pigment that gives the skin its natural
colour. Melanin is made in the skin by pigment cells called
melanocytes. After our skin is exposed to sunlight, the melanocytes
make more melanin, and so the skin becomes darker.
Melanocytes sometimes grow together in harmless groups or clusters,
which are known as moles. Most people have between 10 and 50 moles and
often they are darker than the surrounding skin.
Melanomas can come up in or near to a mole, but can also appear on
skin that looks quite normal. They develop when the skin pigment cells
(melanocytes) become cancerous and multiply in an uncontrolled way. They
can then invade the skin around them and may also spread to other areas
such as the lymph nodes, liver and lungs.
What causes melanoma?
The most important preventable cause is exposure to too much
ultraviolet light in sunlight, especially during the first 20 years of
life. There is lots of evidence linking melanoma to this, and melanomas
are especially common in white-skinned people who live in sunny
countries. The use of artificial sources of ultraviolet light, such as
sun beds, also raises the risk of getting a melanoma.
Some people are more likely to get a melanoma than others:
People who burn easily in the sun are particularly at risk. Melanoma
occurs most often in fair-skinned people who tan poorly. Often they
have blond or red hair, blue or green eyes, and freckle easily.
Melanomas are less common in dark-skinned people.
Past episodes of severe sunburn, often with blisters, and particularly
in childhood, increase the risk of developing a melanoma. However, not
all melanomas are due to sun exposure, and some appear in areas that are
normally kept covered.
People with many (more than 50) ordinary moles, or with a very large
dark hairy birthmark, have a higher than average chance of getting a
melanoma.
Some people have many unusual (atypical) moles (known as ‘dysplastic
naevi’). They tend to be larger than ordinary moles, to be present in
large numbers, and to have irregular edges or colour patterns. The
tendency to have these ‘dysplastic naevi’ can run in families and
carries an increased risk of getting a melanoma.
The risk is raised if another family member has had a melanoma.
People who have already had one melanoma are at an increased risk of getting another one.
People with a damaged immune system (e.g. as a result of an HIV
infection or taking immunosuppressive drugs, perhaps after an organ
transplant) have an increased chance of getting a melanoma.
Are melanomas hereditary?
About 1 in 10 of people with a melanoma have family members who have
also had one. There are several reasons for this. Fair skin is
inherited; dysplastic naevi can run in families, as can a tendency to
have large numbers of ordinary moles.
What are the symptoms of melanoma?
Melanomas may not cause any symptoms at all, but tingling or itching
may occur at an early stage. Some melanomas start as minor changes in
the size, shape or colour of an existing mole (see below): others begin
as a dark area that can look like a new mole. Later on a melanoma may
feel hard and lumpy, and bleed, ooze or crust up.
What does a melanoma look like?
All melanomas do not look the same, and there are several different
types. The ABCD system (below) tells you some of the things to look out
for.
A melanoma may show one or more of the following features:
Asymmetry – the two halves of the area differ in their shape.
Border – the edges of the area may be irregular or blurred, and sometimes show notches.
Colour – this may be uneven. Different shades of black, brown and pink may be seen.
Diameter - most melanomas are at least 6 mm. in diameter.
Melanomas can appear on any part of the skin but they are most common in men on the body, and in women on the legs.
How is a melanoma diagnosed?
If you are at all worried about changes in a mole, or about a new
area of pigmentation appearing on your skin, you should see your family
doctor. The ABCD changes listed above can sometimes be found in
completely harmless conditions, and your doctor will often be able to
put your mind at rest quickly. However, if there is still any doubt,
your doctor will usually refer you to a specialist (a dermatologist or a
surgeon with a special interest in pigmented lesions) who will examine
the area, perhaps with a special instrument (a dermatoscope), and decide
whether it needs to be removed. The only way in which the diagnosis of
a melanoma can be made firmly is by looking at the suspected area under
microscope in the laboratory.
If the mole needs to be examined further, the whole of the suspicious
area will then be removed under a local anaesthetic (an excision
biopsy) and sent to the laboratory to be examined. If the area is too
large to remove easily, a sample of it (a biopsy) will be taken. If a
melanoma is found, the biopsy specimen will provide valuable information
about its type and depth that will help to plan the next step in
treatment.
Can a melanoma be cured?
Yes: three quarters of the people who have a melanoma removed will
have no further problems. However it is crucial for a melanoma to be
removed as early as possible - before it has had time to spread deep
into the skin or to other parts of the body. The thinner the melanoma is
when it is removed; the better is the survival rate. This is why a
doctor should examine anyone with a suspicious mole or blemish as soon
as possible. In a small minority of people the melanoma may have spread
but further surgery or chemotherapy can often help to control this.
For information about available treatments please visit
this page on the website of the British Association of Dermatologists
